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GAPDH Mouse Monoclonal Antibody（50ug）

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生化試劑（60萬種）、抗體（10萬種）、細胞因子、二抗、ECL發(fā)光液、蛋白marker、激動劑、抑制劑、凋亡試劑盒、BSA、動植物提取物、蛋白酶K...

產品型號：abs137959
廠商性質：生產廠家
更新時間：2025-02-07
訪問量：1826

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詳細介紹

品牌	absin	供貨周期	一周

概述
描述	Glyceraldehyde 3 phosphate dehydrogenase (GAPDH) is well known as one of the key enzymes involved in glycolysis. GAPDH is constitutively abundant expressed in almost cell types at high levels, therefore antibodies against GAPDH are useful as loading controls for Western Blotting. Some pathology factors, such as hypoxia and diabetes, increased or decreased GAPDH expression in certain cell types.
別名	GAPDH, A1 40 kd subunit, Activator 1 40 kd subunit, G3PD, GAPD, G3pdh, Rfc40, Rf-c 40 kd subunit
克隆類別	Monoclonal
反應種屬	H, R, M, Mk, Dg, Ch, Hm, Rabbit,Pg
來源宿主	Mouse
應用	WB: 1:3000~1:10000, IHC: 1:200 , IF/ICC: 1:200,
特異性	GAPDH Mouse Monoclonal antibody detects endogenous levels of total GAPDH protein.

性能
保存方法	Mouse IgG1 in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt
濃度	1mg/ml
分子量	34KD
功能	Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules (By similarity). Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation.
純化方法	Affinity-chromatography
亞細胞定位	Cytoplasm,Cytosol,Nucleus,Cytoplasm,Perinuclear region,Membrane,Cytoplasm,Cytoskeleton,Note:Translocates to the nucleus following S-nitrosylation and interaction with SIAH1, which contains a nuclear localization signal (By similarity). Postnuclear and Perinuclear regions.
序列	MGKVKVGVNGFGRIGRLVTRAAFNSGKVDIVAINDPFIDLNYMVYMFQYDSTHGKFHGTV KAENGKLVINGNPITIFQERDPSKIKWGDAGAEYVVESTGVFTTMEKAGAHLQGGAKRVI ISAPSADAPMFVMGVNHEKYDNSLKIISNASCTTNCLAPLAKVIHDNFGIVEGLMTTVHA ITATQKTVDGPSGKLWRDGRGALQNIIPASTGAAKAVGKVIPELNGKLTGMAFRVPTANV SVVDLTCRLEKPAKYDDIKKVVKQASEGPLKGILGYTEHQVVSSDFNSDTHSSTFDAGAG IALNDHFVKLISWYDNEFGYSNRVVDLMAHMASKE

實驗結果圖

Western blot analysis of Hela (1), Rat brain (2), Rabbit Muscle(3), mouse Muscle(4) with GAPDH mouse mAb.

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上一篇：abs132004Rabbit anti-GAPDH Polyclonal Antibody
下一篇：abs124037Rabbit Anti-GAPDH Polyclonal Antibody（50ul）

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GAPDH Mouse Monoclonal Antibody（50ug）

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