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2022年部分文獻展示：
 

? Suppression of PFKFB3-driven glycolysis restrains endothelial-to-mesenchymal transition and fibrotic response.(IF 38.104)
? Tobacco carcinogen induces tryptophan metabolism and immune suppression via induction of indoleamine 2,3-dioxygenase 1.(IF 38.104)
? Biomimetic Immunosuppressive Exosomes that Inhibit Cytokine Storms Contribute to the Alleviation of Sepsis.(IF 30.849)
? A minimally designed PD-L1-targeted nanocomposite for positive feedback-based multimodal cancer therapy. (IF 26.943)
? Anti-alcoholism drug disulfiram for targeting glioma energy metabolism using BBB-penetrating delivery of fixed-dose combination. (IF 20.722)
? A Mouse-adapted CVA6 Strain Exhibits Neurotropism and Triggers Systemic Manifestations in a Novel Murine Model. (IF 19.568)
? Small-molecule PROTAC mediates targeted protein degradation to treat STAT3-dependent epithelial cancer. (IF 19.456)
? Manganese immunotherapy for treating osteosarcoma: Glycosylating 1V209 anchored MnO2 nanosheets prompt pro-inflammatory macrophage polarization. (IF 18.962)
? Reprogramming dysfunctional dendritic cells by a versatile metabolism nano-intervenor for enhancing cancer combinatorial immunotherapy. (IF 18.962)
? HAp Thermosensitive Nanohydrogel Cavities Act as Brood Pouches to Incubate and Control-Release NSCs for Rapid Spinal Cord Injury Therapy. (IF 18.808)
? Engineering micro oxygen factories to slow tumour progression via hyperoxic microenvironments. (IF 17.694)
? Phosphorylation of Jhd2 by the Ras-cAMP-PKA(Tpk2) pathway regulates histone modifications and autophagy. (IF 17.694)
? A single-cell analysis reveals tumor heterogeneity and immune environment of acral melanoma. (IF 17.694)
? Hepatocyte phosphatase DUSP22 mitigates NASH-HCC progression by targeting FAK. (IF 17.694)
? Inhibiting 3βHSD1 to eliminate the oncogenic effects of progesterone in prostate cancer. (IF 16.988)
? Cytokine nanosponges suppressing overactive macrophages and dampening systematic cytokine storm for the treatment of hemophagocytic lymphohistiocytosis. (IF 16.874)
? Prussian Blue Nanoparticles Stabilize SOD1 from Ubiquitination-Proteasome Degradation to Rescue Intervertebral Disc Degeneration. (IF 16.806)
? Hypoxia-responsive immunostimulatory nanomedicines synergize with checkpoint blockade immunotherapy for potentiating cancer immunotherapy. (IF 16.744)
? Lymphocyte infiltration and thyrocyte destruction are driven by stromal and immune cell components in Hashimoto’s thyroiditis. (IF 14.919)
? The E3 ubiquitin-protein ligase Trim31 alleviates non-alcoholic fatty liver disease by targeting Rhbdf2 in mouse hepatocytes. (IF 14.919)
? Seamless and early gap healing of osteochondral defects by autologous mosaicplasty combined with bioactive supramolecular nanofiber-enabled gelatin methacryloyl (BSN-GelMA) hydrogel. (IF 14.593)
? Verteporfin-mediated on/off photoswitching functions synergistically to treat choroidal vascular diseases. (IF 14.593)
? Biomimetic manganese-based theranostic nanoplatform for cancer multimodal imaging and twofold immunotherapy. (IF 14.593)
? CD301b+ macrophages mediate angiogenesis of calcium phosphate bioceramics by CaN/NFATc1/VEGF axis. (IF 14.593)
? N6-methyladenosine plays a dual role in arsenic carcinogenesis by temporal-specific control of core target AKT1. (IF 14.224)
? Impact and microbial mechanism of continuous nanoplastics exposure on the urban wastewater treatment process. (IF 13.4)
? Acid-Responsive Aggregated Gold Nanoparticles for Radiosensitization and Synergistic Chemoradiotherapy in the Treatment of Esophageal Cancer. (IF 13.281)
? Targeting N7-Methylguanosine tRNA modification blocks hepatocellular carcinoma metastasis after insufficient radiofrequency ablation. (IF 12.91)
? Hsa_circ_0000098 is a novel therapeutic target that promotes hepatocellular carcinoma development and resistance to doxorubicin. (IF 12.658)
? CircPAK1 promotes the progression of hepatocellular carcinoma via modulation of YAP nucleus localization by interacting with 14-3-3ζ. (IF 12.658)
? Mitochondrial calpain-1 activates NLRP3 inflammasome by cleaving ATP5A1 and inducing mitochondrial ROS in CVB3-induced myocarditis. (IF 12.416)
? Clusterin negatively modulates mechanical stress-mediated ligamentum flavum hypertrophy through TGF-β1 signaling. (IF 12.153)
? Notoginsenoside R1-loaded mesoporous silica nanoparticles targeting the site of injury through inflammatory cells improves heart repair after myocardial infarction. (IF 11.799)
? Broad-spectrum and powerful neutralization of bacterial toxins by erythroliposomes with the help of macrophage uptake and degradation. (IF 11.614)
? All-stage targeted therapy for the brain metastasis from triple-negative breast cancer. (IF 11.614)
? Multi-scale integrative analyses identify THBS2+ cancer-associated fibroblasts as a key orchestrator promoting aggressiveness in early-stage lung adenocarcinoma. (IF 11.556)
? AdMSC-derived exosomes alleviate acute lung injury via transferring mitochondrial component to improve homeostasis of alveolar macrophages. (IF 11.556)
? CircRNA DDX21 acts as a prognostic factor and sponge of miR‐1264/QKI axis to weaken the progression of triple‐negative breast cancer. (IF 11.492)
? SlRBP1 promotes translational efficiency via SleIF4A2 to maintain chloroplast function in tomato. (IF 11.277)

我們秉承踏實, 務實，求精和不斷創新的精神為中國科學家提供優質的產品，努力打造屬于中國自己的生物試劑品牌！客戶文章的集中發表是對我們最大的鼓勵和鞭策, 我們將以此為動力，繼續埋頭苦干, 繼續為廣大科學家提供更全面更豐富更優質的產品。